Protein cysteine S-nitrosylation inhibits vesicular uptake of neurotransmitters.
Identifieur interne : 000570 ( Main/Exploration ); précédent : 000569; suivant : 000571Protein cysteine S-nitrosylation inhibits vesicular uptake of neurotransmitters.
Auteurs : Y. Wang [Canada] ; Z. Zhou [Canada] ; T. Leylek [Canada] ; H. Tan [Canada] ; Y. Sun [Canada] ; F E Parkinson [Canada] ; J-F Wang [Canada]Source :
- Neuroscience [ 1873-7544 ] ; 2015.
English descriptors
- KwdEn :
- Acetylcholine (metabolism), Animals, Brain (drug effects), Brain (metabolism), Dopamine (metabolism), Glutamic Acid (metabolism), Mice, Nitric Oxide (metabolism), Nitric Oxide Donors (pharmacology), S-Nitrosoglutathione (analogs & derivatives), S-Nitrosoglutathione (pharmacology), Tritium, Vesicular Acetylcholine Transport Proteins (metabolism), Vesicular Glutamate Transport Protein 1 (metabolism), Vesicular Glutamate Transport Protein 2 (metabolism), Vesicular Monoamine Transport Proteins (metabolism).
- MESH :
- chemical , analogs & derivatives : S-Nitrosoglutathione.
- chemical , metabolism : Acetylcholine, Dopamine, Glutamic Acid, Nitric Oxide, Vesicular Acetylcholine Transport Proteins, Vesicular Glutamate Transport Protein 1, Vesicular Glutamate Transport Protein 2, Vesicular Monoamine Transport Proteins.
- drug effects : Brain.
- metabolism : Brain.
- chemical , pharmacology : Nitric Oxide Donors, S-Nitrosoglutathione.
- Animals, Mice, Tritium.
Abstract
Previous studies have shown that nitric oxide can induce cysteine S-nitrosylation of total protein in synaptosomes, suggesting that nitric oxide may contribute to the regulation of synaptic protein function. Vesicular neurotransmitter transporters pack neurotransmitters into synaptic vesicles and play an important role in neurotransmission. In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is responsible for the uptake of monoamines, vesicular acetylcholine transporter (VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate. The purpose of this study was to investigate the role of cysteine S-nitrosylation in the regulation of these vesicular neurotransmitter transporters. Using the biotin switch assay followed by avidin precipitation and immunoblotting we found that the nitric oxide donor nitrosoglutathione (GSNO) not only increased total cysteine S-nitrosylation, but also increased cysteine S-nitrosylation of VMAT2, VAChT, VGLUT1 and VGLUT2 in the mouse brain. Further, GSNO also decreased the vesicular uptake of [(3)H]dopamine, [(3)H]acetylcholine and [(3)H]glutamate. Our studies suggest that the cysteine S-nitrosylation may play an important role in the regulation of vesicular neurotransmitter transport.
DOI: 10.1016/j.neuroscience.2015.10.052
PubMed: 26541750
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Previous studies have shown that nitric oxide can induce cysteine S-nitrosylation of total protein in synaptosomes, suggesting that nitric oxide may contribute to the regulation of synaptic protein function. Vesicular neurotransmitter transporters pack neurotransmitters into synaptic vesicles and play an important role in neurotransmission. In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is responsible for the uptake of monoamines, vesicular acetylcholine transporter (VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate. The purpose of this study was to investigate the role of cysteine S-nitrosylation in the regulation of these vesicular neurotransmitter transporters. Using the biotin switch assay followed by avidin precipitation and immunoblotting we found that the nitric oxide donor nitrosoglutathione (GSNO) not only increased total cysteine S-nitrosylation, but also increased cysteine S-nitrosylation of VMAT2, VAChT, VGLUT1 and VGLUT2 in the mouse brain. Further, GSNO also decreased the vesicular uptake of [(3)H]dopamine, [(3)H]acetylcholine and [(3)H]glutamate. Our studies suggest that the cysteine S-nitrosylation may play an important role in the regulation of vesicular neurotransmitter transport.</div>
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